| lncRNA在癌细胞生长和代谢中的作用研究进展 |
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| 引用本文： | 田海华12 李静秋1 杨 杰1 龚朝辉1. lncRNA在癌细胞生长和代谢中的作用研究进展[J]. 宁波大学学报(理工版), 2017, 0(6): 90-97 |
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| 作者姓名： | 田海华12 李静秋1 杨 杰1 龚朝辉1 |
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| 作者单位： | (1.宁波大学 医学院, 浙江 宁波 315211; 2.宁波市康宁医院, 浙江 宁波 315201) |
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| 摘 要： | 从长链非编码RNA(long non-coding RNA, lncRNA)与癌细胞生长和代谢的关系角度, 系统地分析和综述了lncRNA如何通过促进或抑制细胞周期进程调节癌细胞生长, lncRNA如何通过调节上皮间质转化影响癌细胞迁移, 以及lncRNA在肿瘤细胞糖类和脂类代谢中如何发挥其作用.
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| 关 键 词： | 长链非编码RNA 细胞周期 细胞迁移 肿瘤代谢 肿瘤标志物 |
Function of long non-coding RNA in cancer cell growth and metabolism |
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| TIAN Hai-hua1,2,LI Jing-qiu1,YANG Jie1,GONG Zhao-hui1. Function of long non-coding RNA in cancer cell growth and metabolism[J]. Journal of Ningbo University(Natural Science and Engineering Edition), 2017, 0(6): 90-97 |
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| Authors: | TIAN Hai-hua1 2 LI Jing-qiu1 YANG Jie1 GONG Zhao-hui1 |
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| Affiliation: | ( 1.Medical School, Ningbo University, Ningbo 315211, China; 2.Ningbo Kangning Hospital, Ningbo 315201, China ) |
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| Abstract: | Long non-coding RNAs (lncRNAs) are widely found in human cells and involve in vital life processes of gene expression, epigenetic regulation and X-chromosome inactivation. They are suggested to be closely related to tumorigenesis and growth suppression. The review focuses on the role of lncRNA in cancer cell growth and metabolism. A growing body of evidence suggests that lncRNA regulates cancer cell growth by promoting or inhibiting cell cycle. In addition, the review includes how lncRNA affects epithelial-mesenchymal transition (EMT)-mediated cell migration, and how lncRNA functions as a regulator in the glucose and lipid metabolism in tumor cells |
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| Keywords: | lncRNA cell cycle cell migration tumor metabolism tumor biomarker |
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