Vicinal functionalization of propiolate esters via a tandem catalytic carbocupration-Mukaiyama aldol reaction sequence |
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| Authors: | Mueller Amanda J Jennings Michael P |
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| Affiliation: | Department of Chemistry, The University of Alabama, Tuscaloosa, AL 35487-0336, USA. |
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| Abstract: | The vicinal functionalization of propiolate esters via a tandem catalytic carbocupration-Mukaiyama aldol reaction sequence has been investigated. It has been shown that catalyst loadings as low as 8 mol % readily allow for good yields and excellent diastereoselectivities (>20:1) for a series of Grignard reagents and aldehydes. |
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