Boron binding with the quorum sensing signal AI-2 and analogues |
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| Authors: | Semmelhack Martin F Campagna Shawn R Hwa Charlotte Federle Michael J Bassler Bonnie L |
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| Institution: | Departments of Chemistry and Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA. |
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| Abstract: | reaction: see text] The unstable bacterial metabolic product, DPD, and the related natural product, laurencione, are shown to have a high affinity for borate complexation, through the hydrated analogue. The boron complex of DPD is Vibrio harveyi AI-2, an interspecies quorum sensing signal in bacteria, and an affinity column with a borate resin is effective in providing the first method for concentrating and purifying V. harveyi AI-2 from the biosynthetic product. |
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