Properties of oil1/water/oil2 double emulsions containing lipophilic acrylic polymer

Stable oil₁/water/oil₂ (o₁/w/o₂) double emulsions (DEs) containing glyceryl monooleate as a promoter of skin permeability in internal ultradispersed phase o1 (heptane) and an acrylic polymer as a pressuresensitive adhesive in external dispersion medium o₂ (ethyl acetate) are obtained. The aqueous interlayer of the DEs contains Tween 80, hydroxypropyl cellulose, and sometimes lysozyme. The phase ratio in the emulsions is constant. The effect of polyacrylate concentration on the stability, microstructure, and rheological properties of DEs is studied. Factors of DE stability, with the viscoelastic properties of the external dispersion medium being of the most importance, are analyzed. The DEs are used to produce ultradisperse films, which exhibit long-term release of lysozyme at a constant rate with its enzymatic activity retained preserved. The diffusion coefficient of the protein in the polymer matrix is determined.