Specific photodissociation of peptides with multi-stage mass spectrometry |
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Authors: | Tabarin Thibault Antoine Rodolphe Broyer Michel Dugourd Philippe |
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Institution: | Laboratoire de Spectrométrie Ionique et Moléculaire, UMR 5579 (Université Lyon I et CNRS), 43 Bd du 11 Novembre 1918, 69622 Villeurbanne cedex, France. |
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Abstract: | We report collision-induced dissociation (CID) and laser-induced dissociation (LID) performed at different wavelengths between 220 and 280 nm of the peptides leucine-enkephalin (protonated) and gramicidin A (sodiated). Hydrogen-atom losses and side-chain cleavages were observed in LID experiments. These losses depend on the laser wavelength and lead to the formation of radical ions. The fragmentations of these radicals, which are not observed in CID experiments, were investigated in multi-stage mass spectrometry experiments. |
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