Transition metal complexes of a potential anticancer quinazoline ligand |
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| Authors: | Kalagouda B. Gudasi Siddappa A. Patil Manohar V. Kulkarni Munirathinam Nethaji |
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| Affiliation: | (1) Department of Chemistry, Karnatak University, Dharwad, 580003, India;(2) Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore, 560012, India |
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| Abstract: | A new heterocycle, namely 2-(furyl)-3-(furfuralimino)-1,2-dihydroquinazolin-4(3H)-one (ffdq) was formed by the condensation of 2-aminobenzoylhydrazide with furfural and characterized by physico-chemical, spectroscopic, and single crystal X-ray diffraction studies. A series of complexes of ffdq have been synthesized and characterized by physico-chemical, spectroscopic, and thermal studies. According to the i.r. and 1H-n.m.r. spectra ffdq behaves as a bidentate ligand coordinating through quinazoline oxygen and azomethine nitrogen. The FAB-mass spectrum of the Cd(II) complex indicates the monomeric nature of this complex. The X-band e.p.r. spectrum of the Cu(II) complex and thermal stabilities of the Co(II) and Ni(II) complexes are discussed. |
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