Lamellar phase of stacked two-dimensional rafts of actin filaments |
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| Authors: | Wong Gerard C L Lin Alison Tang Jay X Li Youli Janmey Paul A Safinya Cyrus R |
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| Institution: | Materials Department, Physics Department, Biomolecular Science and Engineering Program, University of California, Santa Barbara, California 93106, USA. gclwong@uiuc.edu |
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| Abstract: | We examined liquid crystalline phases of the cytoskeletal polyelectrolyte filamentous (F-)actin in the presence of multivalent counterions. As a function of increasing ion concentration, the F-actin rods in either an isotropic or a nematic phase will transform into a new and unexpected lamellar phase of cross-linked rafts (L(XR) phase), before condensing into a bundled phase of parallel, close-packed rods. This behavior is generic for alkali earth divalent ions Mg2+, Ca2+, Sr2+, and Ba2+, and the structural transitions are achieved without any architecture-specific actin-binding linker proteins. |
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