Melidianolic acid A and B, new antimalarial acyclic diterpenes from Aphanamixis grandifolia |
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| Authors: | Astulla Adil Hirasawa Yusuke Rahman Abdul Kusumawati Idha Ekasari Wiwied Widyawaruyanti Aty Zaini Noor Cholies Morita Hiroshi |
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| Institution: | Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo 142-8501, Japan. |
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| Abstract: | Two new acyclic diterpenes, melidianolic acids A (1) and B (2), have been isolated from the bark of Aphanamixis grandifolia. Their structures were elucidated on the basis of spectroscopic and chemical methods. Melidianolic acids A (1) and B (2) showed antimalarial activity against Plasmodium falciparum 3D7 with IC50 of 6.1 and 7.3 microg/mL, respectively. |
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