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Preparation of a chiral azadiene for the synthesis of 5-aza analogues of angucyclinones |
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| Authors: | Drissa Sissouma,Geoffroy DequirezSylvain Collet,André Guingant |
| Affiliation: | a Université de Nantes, CNRS, Chimie et Interdisciplinarité: Synthèse, Analyse, Modélisation (CEISAM), UMR CNRS n° 6230, 2, rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3, France b Laboratoire de Chimie Organique Structurale, UFR SSMT, Université de Cocody-Abidjan, Côte d’Ivoire |
| Abstract: | We have developed an efficient synthesis of both enantiomers of a key azadiene for the preparation of 5-aza analogues of angucyclinones through a hetero Diels-Alder reaction. These dienes were efficiently prepared via a 4-step procedure from known and readily available chiral diketoesters. |
| Keywords: | Chiral azadiene Hetero Diels-Alder reaction Aza-angucyclinone Enaminone Ester hydrolysis |
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