|
|||||
|
|
Stereoselective total synthesis of (−)-brevisamide |
|
| Authors: | JS Yadav N Mallikarjuna ReddyMd Ataur Rahman AR PrasadBV Subba Reddy |
| Institution: | Centre for Semiochemicals, CSIR, Indian Institute of Chemical Technology, Hyderabad 500007, India |
| Abstract: | The stereoselective total synthesis of (−)-brevisamide, a novel marine cyclic ether alkaloid isolated from dinoflagellate karenia brevis is described. The key steps involved in this synthesis are the Sharpless asymmetric epoxidation and regioselective ring opening of chiral epoxide by Gilman's reagent. The tetrahydropyran core has been constructed by an intramolecular SN2 cyclisation. |
| Keywords: | Sharpless asymmetric epoxidation Gilman's reaction SN2 cyclisation TEMPO-BIAB oxidation Horner&ndash Wadsworth&ndash Emmons reaction |
| 本文献已被 ScienceDirect 等数据库收录！ | |