Copper-mediated cyanation of aryl boronic acids using benzyl cyanide |
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| Authors: | Yan Luo Qiaodong WenZhiyuan Wu Jisong JinPing Lu Yanguang Wang |
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| Affiliation: | Department of Chemistry, Zhejiang University, Hangzhou 310027, China |
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| Abstract: | An efficient copper-mediated synthesis of aryl nitriles from aryl boronic acids has been achieved using benzyl cyanide as a user-friendly cyanide source. Various aryl boronic acids underwent the reaction smoothly, affording the corresponding aryl nitriles in moderate to good yields. tert-Butyl hydroperoxide (TBHP) was found to be a critical agent facilitating the cyanation reaction. |
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| Keywords: | Copper catalysis Cyanation Benzyl cyanide Boronic acid C&ndash H oxidation |
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