Copper on iron promoted one-pot synthesis of β-aminoenones and 3,5-disubstituted pyrazoles |
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Authors: | Szabolcs Kovács Zoltán Novák |
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Institution: | Eötvös Loránd University, Pázmány Péter stny. 1/a, Budapest 1117, Hungary |
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Abstract: | The reaction of hydroximoyl chlorides with acetylenes in the presence of a copper on iron bimetallic system leads to β-aminoenones via reductive ring opening of isoxazole intermediates. The valuable β-aminoenone building blocks can be isolated or transformed into pyrazoles with the addition of hydrazine in a straightforward one-pot procedure. |
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Keywords: | Copper Enones Iron Heterocycles Reduction |
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