Cascade reaction synthesis of multisubstituted bicyclic pyridone derivatives |
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| Authors: | Xuebing Chen Dandan ZhuXiaoying Wang Shengjiao Yan Jun Lin |
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| Institution: | Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China |
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| Abstract: | An efficient synthesis of novel bicyclic pyridone derivatives via cascade reaction of heterocyclic ketene aminals (HKAs) and 4-arylmethylene-2-phenyloxazol-5(4H)-ones in the presence of acetic acid has been established. Significantly, the protocol affords a straightforward approach to the construction of multisubstituted bicyclic pyridones in which one C–O bond was cleaved and new C–C and C–N bonds were formed in one pot under mild conditions. |
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| Keywords: | Bicyclic pyridones Cascade reaction Heterocyclic ketene aminals 2-Phenyloxazol-5(4H)-ones |
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