Palladium-catalyzed one-pot synthesis of benzo[b][1,6]naphthyridines via Sonogashira coupling and annulation reactions from 2-chloroquinoline-3-carbonitriles |
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Authors: | Radhey M. Singh Ritush KumarNeha Sharma Mrityunjaya Asthana |
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Affiliation: | Department of Chemistry, Centre of Advance Studies, Banaras Hindu University, Varanasi, U.P., India |
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Abstract: | Palladium-catalyzed one-pot synthesis of 1,3-disubstituted benzo[b][1,6]naphthyridines and [1,6]naphthyridines has been described from easily accessible precursors, 2-chloroquinoline-3-carbonitriles and 2-chloropyrido-3-carbonitrile via sequential additions of palladium-catalyst for Sonogashira-coupling and the following annulations in good to excellent yields. A plausible mechanism for annulation is discussed. |
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Keywords: | Palladium One-pot 2-Chloroquinoline-3-carbonitrile Intramolecular [1,6]Naphthyridine |
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