Novel isocyanide-based three-component reaction: a facile synthesis of substituted 1H-chromeno[2,3-d]pyrimidine-5-carboxamides |
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| Authors: | Ebrahim Soleimani Somayeh Ghorbani Hamid Reza Ghasempour |
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| Affiliation: | 1. Department of Chemistry, Razi University, Kermanshah 67149-67346, Iran;2. Department of Biotechnology and Chemical Engineering, Islamic Azad University, Science and Research Branch, Kermanshah, Iran |
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| Abstract: | A mild and efficient method for the synthesis of 1H-chromeno[2,3-d]pyrimidine-5-carboxamide derivatives via a one-pot, three-component reaction of an isocyanide, barbituric acid, and a salicylaldehyde in the presence of acetic acid in ethanol/water mixture at 75 °C is reported. This high atom economy reaction led to the construction of one benzopyran ring, and one amide group in a single synthetic step. |
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| Keywords: | Chromeno[2,3-d]pyrimidine Multicomponent reactions Benzopyran Salicylaldehyde Barbituric acid Isocyanide |
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