Efficient synthesis of quinoxalines with hypervalent iodine as a catalyst |
| |
| Authors: | Chung-Yu Chen Wan-Ping Hu Mei-Chun Liu Pi-Cheng Yan Jeh-Jeng Wang Mei-Ing Chung |
| |
| Institution: | 1. Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan;2. School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan;3. Department of Biotechnology, Kaohsiung Medical University, Taiwan |
| |
| Abstract: | Various biologically important quinoxalines were efficiently synthesized in excellent yields via one-pot reaction between 1,2-diaminobenzenes and internal alkynes. The method utilizes inexpensive and readily available hypervalent iodine source, such as (diacetoxyiodo)benzene (PhI(OAc)2) and proved to be a better alternative as compared to expensive transition metal catalysts. Quinoxaline 4i (2-phenyl-3-(3,4,5-trimethoxy phenyl)quinoxaline)] was evaluated for leukemia cancer cell lines and turned out to be a good candidate. |
| |
| Keywords: | Quinoxaline PhI(OAc)2 Combretastatin A4 One-pot reaction Anti-cancer |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
