An efficient copper-catalyzed N-arylation of amides: synthesis of N-arylacrylamides and 4-amido-N-phenylbenzamides |
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| Authors: | Zheng-Jun Quan Hai-Dong Xia Zhang Zhang Yu-Xia Da Xi-Cun Wang |
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| Institution: | 1. Key Laboratory of Eco-Environment-Related Polymer Materials, Ministry of Education, China, Gansu 730070, PR China;2. Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering, Northwest Normal University, Anning East Road 967#, Lanzhou, Gansu 730070, PR China |
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| Abstract: | Copper-catalyzed intermolecular C–N bond-forming reactions between aryl iodides and amides are described using sodium ascorbate, which is both cheap and nontoxic, as the additive. A variety of functionalized amides including some practical, unique secondary amides, such as N-arylacrylamides and 4-amido-N-phenylbenzamides, which are difficult to obtain by the classical methods, are prepared. Furthermore, some tertiary amides are prepared by using copper thiophenecarboxylate. |
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| Keywords: | Copper N-Arylation Amides Aryl iodides C&ndash N cross-coupling |
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