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Synthesis of indoles with a polyfluorinated benzene ring |
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| Authors: | Larisa V. Politanskaya Igor P. ChuikovVitalij D. Shteingarts |
| Affiliation: | N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of Russian Academy of Sciences, Ac. Lavrentiev Avenue 9, 630090 Novosibirsk, Russian Federation |
| Abstract: | A two-step sequence consisting of a Sonogashira coupling of polyfluorinated 2-iodoanilines with terminal alkynes, followed by a KOH promoted cyclization of the 2-alkynylanilines thus formed, has been developed as a one-pot synthesis of 2-R-indoles (R=n-Bu, Ph, CH2OTHP→CH2OH, C(CH3)2OH→H) containing a polyfluorinated benzene moiety. |
| Keywords: | Coupling reactions Cyclization of polyfluorinated ortho-alkynylanilines Polyfluorinated indoles One-pot synthesis |
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