A novel multicomponent reaction involving isoquinoline,allenoate and activated ketone |
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| Authors: | Hai-Bin Yang Yun-Zhou ZhaoRui Sang Xiang-Yin TangMin Shi |
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| Institution: | State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China |
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| Abstract: | The reaction of isoquinoline and allenoate with activated ketone resulted in a novel three component reaction, affording 1,3]oxazino2,3-a]isoquinoline derivatives in moderate yields along with moderate diastereoselectivities via 1,4-dipolar cycloaddition. It was also found that when isatins were used as substrates, the regioselectivity of cycloadducts was different from those using ethyl trifluoropyruvate as substrate. |
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| Keywords: | Isatin Isoquinoline Allenoate Zwitterion Trifluoropyruvate |
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