Synthesis and structure of condensed triazolo- and tetrazolopyrimidines |
| |
Authors: | Samvel N. Sirakanyan Athina Geronikaki Domenico Spinelli Anush A. Hovakimyan Azat S. Noravyan |
| |
Affiliation: | 1. The Scientific Technological Center of Organic and Pharmaceutical Chemistry, Armenian Academy of Science, Institute of Fine Organic Chemistry of A.L. Mnjoyan, Ave. Azatutyan 26, Yerevan 0014, Armenia;2. Aristotle University of Thessaloniki, School of Pharmacy, Thessaloniki 54124, Greece;3. Dipartimento di Chimica G. Ciamician, Università degli Studi di Bologna, Bologna 40126, Italy |
| |
Abstract: | Herein we present the synthesis of several new hydrazino derivatives of cyclopenta[c]pyridine, 5,6,7,8-tetrahydroisoquinoline and pyrano[3,4-c]pyridine from 3-oxo-4-cyano fused pyridine derivatives. The hydrazino derivatives obtained were used as starting materials for the synthesis of isomeric triazolopyrimidines as well as tetrazolopyrimidines. Furthermore, the rearrangement of triazolopyrimidines 7 into triazolopyrimidines 8 is also presented. In DMSO tetrazolopyrimidines 10 were shown to be in equilibrium with the relevant azidopyrimidines 9. The tetrazolopyrimidine structure was confirmed by X-ray crystallography. The synthesized compounds were tested for their antimicrobial activity. |
| |
Keywords: | Triazolopyrimidines Tetrazolopyrimidines Azidopyrimidines Antimicrobial activity |
本文献已被 ScienceDirect 等数据库收录! |
|