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Sequential alkylation/cyclization/isomerization of ethyl 3-(o-trifluoroacetamidoaryl)-1-propargylic esters: a new route to 2-acyl- and 2-ethoxycarbonyl-3-alkenyl indoles |
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| Authors: | Ilaria Ambrogio Antonio Arcadi Sandro Cacchi Giancarlo Fabrizi Antonella Goggiamani Fabio Marinelli |
| Affiliation: | 1. Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, P.le A. Moro 5, 00185 Rome, Italy;2. Dipartimento di Scienze Fisiche e Chimiche, Università di L''Aquila, Via Vetoio, 67010 L''Aquila, Italy |
| Abstract: | The reaction of ethyl 3-(o-trifluoroacetamidoaryl)-1-propargylic esters with ethyl iodoacetate or α-bromoacetophenone in the presence of K2CO3 in DMSO provides a new simple access to 2-acyl- and 2-ethoxycarbonyl-3-alkenyl indoles. |
| Keywords: | Propargylic carbonates Indoles Sequential reactions Cyclization Intramolecular SN2&prime |
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