A novel synthesis of diverse 2-amino-5-hydroxy-4H-chromene derivatives with a spirooxindole nucleus by Ca(OH)2-mediated three-component reactions of substituted resorcinols with isatins and malononitrile |
| |
| Authors: | Ji Hyang Park Yong Rok Lee Sung Hong Kim |
| |
| Institution: | 1. School of Chemical Engineering, Yeungnam University, Gyeongsan 712-749, Republic of Korea;2. Analysis Research Division, Daegu Center, Korea Basic Science Institute, Daegu 702-701, Republic of Korea |
| |
| Abstract: | An efficient and facile one-pot synthesis is described for the preparation of novel 2-amino-5-hydroxy-4H-chromene derivatives with a spirooxindole nucleus using Ca(OH)2-mediated three-component reactions of substituted resorcinols with isatins and malononitrile. This simple method provided a variety of biologically interesting diverse 2-amino-5-hydroxy-4H-chromene derivatives in moderate yields under mild reaction conditions. |
| |
| Keywords: | Multi-component reaction One-pot synthesis Resorcinols Isatin Malononitrile Calcium hydroxide |
| 本文献已被 ScienceDirect 等数据库收录！ |
