8-羟基喹啉化学修饰壳聚糖亚铁配合物的合成及结构表征

为了利用高分子壳聚糖的生物特性降低药物的毒副作用,寻找理想的高分子药物载体,增加药物的生物特性,本文以高分子壳聚糖为载体,以8-羟基喹啉对其进行共价修饰,合成了喹啉类抗疟杀菌药的高分子药物前体,为增加其活性,与亚铁配位,合成了壳聚糖-8-羟基喹啉-亚铁配合物,用元素分析、TG-DTA分析、IR光谱、UV光谱和荧光光谱等研究了配合物的性质,并优化了配合物合成条件.结果表明,CTS-HQ对Fe²⁺离子的吸附等温线符合Langmuir吸附等温线方程,在室温下,pH=4时吸附8h的饱和吸附量Q_max=86.96mg/g,K=1.474J/mg.

Synthesis and Characterization of 8-Hydroxy Quinoline Chemically Modified Macromolecule Chitosan and Its Ferrous Complex

In order to enhance biologic applicability of medicament and to reduce their medicial toxicity, chitosans ramification was derived from chitosan and 8-hydroxy quinoline through covalently binding between amido in chitosan and 5-chloromethyl-8-quinolinol hydrochloride, and its complex of ferrous were synthesized. Their compositions and structures were characterized by elementary analysis, IR spctra, UV-Vis spectra, fluorescence spectrophotometry and thermal analysis. It was found that the coordination was realized through binding of N, O in 8-hydroxy quinoline with the Fe(Ⅱ) in the ferrous complex. The optimizing coordination condition of ferrous complex that the reaction was carried out under stirring at 40 ℃ and pH=4 for 8 h. The sorption isotherm and sorption kinetics of CTS-HQ for ferrous ions were investigated and the results were satisfied with the Langmuir-single-molecule-layer adsorption mechanism. The apparent adsorption velocity constant K is 1.474 J/mg and the saturated sorption capacity Q is 86.96 mg/g at 293.15 K.