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Industrial production of L-2-amino-4-phenylbutyric acid from 2-oxo-4-phenylbutyric acid by paracoccus denitrificans containing aminotransferase activity |
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| Authors: | Masaru Senuma Katsuhiko Nakamichi Koichi Nabe Shigeru Nishimoto Tetsuya Tosa |
| Institution: | 1. Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co.Ltd., 16-89, Kashima-3-chome, Yodogawa-ku, 532, Osaka, Japan |
| Abstract: | An industrial production method of L-2-amino-4-phenylbutyric acid from 2-oxo-4-phenylbutyric acid by microbial cells containing aminotransferase activity was investigated. By usingParacoccus denitrificans pFPr-1, 0.19M L-2-amino-4-phenylbutyric acid was produced with a 95% conversion yield. Accumulated L-2-amino-4-phenylbutyric acid was readily isolated in pure form. Overall yield from 2-oxo-4-phenylbutyric acid was 83.7%. |
| Keywords: | Index Entries" target="_blank">Index Entries L-2-Amino-4-phenylbutyric acid enzyme production of and conversion of 2-oxo-4-phenylbutyric acid to 2-oxo-4-phenylbutyric acid L-2-amino-4-phenylbutyric acid production from aminotransferase activity inParacoccus denitrificans Paracoccus denitrificans useful aminotransferase source for L-2-amino-4-phenylbutyric acid production |
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