A novel synthesis of amino-1,2-oxazinones as a versatile synthon for beta-amino acid derivatives |
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| Authors: | Miyata Okiko Namba Megumi Ueda Masafumi Naito Takeaki |
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| Institution: | Kobe Pharmaceutical University, Motoyamakita, Higashinada, Kobe 658-8558, Japan. |
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| Abstract: | The radical addition-cyclisation of alpha, beta-unsaturated hydroxamates containing an oxime ether provides a novel method for the stereoselective synthesis of amino-1,2-oxazinones. Its synthetic utility is demonstrated by a stereoselective synthesis of beta-amino acid derivatives, such as alpha-alkyl-beta-amino-gamma-lactone and alpha,beta-disubstituted beta-lactam. |
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