| 类模板分子印迹整体柱测定甲氧苄啶的研究 |
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| 引用本文： | 张红武,史美丽,李康,卢绮雯,翟海云.类模板分子印迹整体柱测定甲氧苄啶的研究[J].分析测试学报,2011,30(11):1283-1289. |
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| 作者姓名： | 张红武 史美丽 李康 卢绮雯 翟海云 |
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| 作者单位： | 1. 广东药学院药科学院,广东广州,510006
2. 广东药学院门诊部,广东广州,510006 |
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| 基金项目： | 国家自然科学青年基金资助项目（21005021） |
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| 摘 要： | 利用三聚氰胺(MAM)与甲氧苄啶(TMP)分子中嘧啶环局部结构类似的特性,以三聚氰胺为类模板分子,甲基丙烯酸(MAA)为功能单体,二甲基丙烯酸乙二醇酯(EDMA)为交联剂,原位聚合法制备了对甲氧苄啶(TMP)有识别作用的分子印迹(MIP)整体柱.在优化的色谱条件下,该印迹整体柱对甲氧苄啶显示出选择性识别作用,而对叶酸、...
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| 关 键 词： | 甲氧苄啶 类模板 分子印迹聚合物 整体柱 高效液相色谱 |
Determination of Trimethoprim with Molecularly Imprinted Monolithic Column by Employing an Analogue Template |
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| ZHANG Hong-wu,SHI Mei-li,LI Kang,LU Qi-wen,ZHAI Hai-yun.Determination of Trimethoprim with Molecularly Imprinted Monolithic Column by Employing an Analogue Template[J].Journal of Instrumental Analysis,2011,30(11):1283-1289. |
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| Authors: | ZHANG Hong-wu SHI Mei-li LI Kang LU Qi-wen ZHAI Hai-yun |
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| Institution: | ZHANG Hong-wu1*,SHI Mei-li2,LI Kang1,LU Qi-wen1,ZHAI Hai-yun1(1.School of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006,China,2.The Affiliated Out-Patient Department,China) |
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| Abstract: | Melamine was employed as an analogue template to prepare a molecularly imprinted monolithic column which presents the ability of selective recognition to trimethoprim(TMP) because of the similarity between melamine molecule and substructure of trimethoprim.Methacrylic acid was applied as a functional monomer and ethylene glycol dimethacrylate as a cross linker during the in-situ polymerization process.Under the optimal conditions,the imprinted monolithic column showed a selective recognition to TMP when usi... |
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| Keywords: | trimethoprim analogue template molecularly imprinted polymer monolithic column HPLC |
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