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Synthesis of rigidly-linked vancomycin dimers and their in vivo efficacy against resistant bacteria |
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| Authors: | Lu Jun Yoshida Osamu Hayashi Sayaka Arimoto Hirokazu |
| Institution: | Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa, Nagoya, 464-8602, Japan. |
| Abstract: | A novel and efficient avenue for the preparation of dimeric vancomycins is described, and the dimers exhibited excellent antibacterial activities in the murine infection model. |
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