可天宁印迹聚合物分子识别特性的光谱与XPS研究

以可天宁(COT)为模板分子，甲基丙烯酸(MAA)为功能单体，乙二醇二甲基丙烯酸酯为交联剂，合成了一种新型的分子印迹聚合物。采用紫外光谱、X射线光电子能谱、红外光谱和1H NMR波谱研究了印迹聚合物的结合位点和识别机理。结果表明，该聚合物通过协同氢键作用形成1∶2型配合物，专一地结合可天宁分子。MAA分子羧基上的氢原子是氢键的质子给予体;COT分子吡啶环上的氮原子以及羰基上的氧原子是质子的接受体，是与MAA形成氢键作用的选择性识别位点。

Spectroscopy and XPS Studies on Molecular Recognition of a Molecularly Imprinted Cotinine-Specific Polymer

In the present study,molecular imprinting technique was used to develop a method based on noncovalent interaction for the systhesis of a cotinine-specific polymer.The molecular recognition characteristics of the template polymer were evaluated by UV,IR,XPS and 1H NMR.The results indicated that the interactions should be cooperative hydrogen bonds produced by self-assembling of the template and the monomer.The stoichiometric mole ratio of COT-MAA complex is 1:2.Furthermore,nitrogen atom of the pyridine ring and oxygen atom of the lactam group in cotinine molecular are hydrogen-bond acceptors,being the predominant binding sites interacting with the functional monomer.