| 三齿配体杂环五配位有机锡化合物的合成与生物活性 |
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| 引用本文： | 李娟,尹瑜,李志强. 三齿配体杂环五配位有机锡化合物的合成与生物活性[J]. 合成化学, 2007, 15(2): 176-180 |
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| 作者姓名： | 李娟 尹瑜 李志强 |
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| 作者单位： | 湖南大学,化学化工学院,湖南,长沙,410082 |
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| 摘 要： | 邻氨基苯酚与邻羟基芳香醛(酮)反应,合成了4个三齿Schiff碱配体(2a,2d,2g和2j),2分别与二苄基二氯化锡,二苯基二氯化锡,二正丁基二氯化锡反应合成了12个未见文献报道的三齿配体杂环五配位有机锡配合物(3a~3l),其结构经1HNMR,IR和元素分析确证。体外抗菌和抗癌活性测试结果表明,3b,3c,3f,3i和3k具有较强的抑菌活性;3c和3l具有较好的抗癌活性。
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| 关 键 词： | 氨基苯酚 三齿Schiff碱配体 有机锡配合物 合成 抗菌活性 抗癌活性 |
| 文章编号： | 1005-1511（2007）02-0176-05 |
| 收稿时间： | 2006-10-08 |
| 修稿时间： | 2006-10-08 |
Synthesis and Biological Activity of Heterocyclic Pentacoordinated Organotin Complexes Derived from Tridentate Schiff Bases |
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| LI Juan,YIN Yu,LI Zhi-qiang. Synthesis and Biological Activity of Heterocyclic Pentacoordinated Organotin Complexes Derived from Tridentate Schiff Bases[J]. Chinese Journal of Synthetic Chemistry, 2007, 15(2): 176-180 |
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| Authors: | LI Juan YIN Yu LI Zhi-qiang |
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| Affiliation: | College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China |
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| Abstract: | Twelve novel heterocyclic pentacoordinated organotin complexes(3a~3l) were synthesized from dialkyltin dichlorate(or diaryltin dichlorate) and tridentate Schiff base ligand,which were obtained from 2-aminophenol and o-hydroxyarylaldehyde by the condensation.The structure of 3 were characterized by 1H NMR,IR and elemental analysis.The antibacterial and anticancer activities in vitro were determined.The results showed that 3b,3c,3f,3i and 3k exhibited strong antibacterial activities, 3c and 3l exhibited certain anticancer activities. |
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| Keywords: | aminophenol tridentate Schiff base ligand organotin complex synthesis antibacterial activity anticancer activity |
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