Rh-Catalyzed asymmetric hydrogenation of (Z)-ethyl 3-acetamido-2-butenoate in supercritical carbon dioxide: the effect of cosolvents |
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| Authors: | Lyubimov S E Rastorguev E A Petrovskii P V Davankov V A |
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| Institution: | 1.A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 ul. Vavilova, 119991, Moscow, Russian Federation
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| Abstract: | Rh-Catalyzed asymmetric hydrogenation (up to 85% ee) of (Z)-ethyl 3-acetamido-2-butenoate was carried out for the first time in supercritical CO2 using protic cosolvents. The activity of the Rh catalyst bearing the amidophosphite ligand increases with an increase in
acidity of the protic cosolvents and with hydrogen pressure. |
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