New Cyclic Diarylheptanoids from Platycarya strobilacea |
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| Authors: | Wen-bing Ding Rui-yuan Zhao Guan-hua Li Bing-lei Liu Hua-liang He Lin Qiu Jin Xue You-zhi Li |
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| Institution: | 1.Hunan Provincial Engineering and Technology Research Center for Biopesticide and Formulation Processing, Hunan Agricultural University, Changsha 410128, China;2.National Research Center of Engineering and Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, China; (G.-h.L.); (H.-l.H.); (L.Q.); (J.X.);3.Hunnan Cotton Science Institute, Changde 415100, China; (R.-y.Z.); (B.-l.L.) |
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| Abstract: | Five new cyclic diarylheptanoids (platycary A–E, compounds 1–5) and three previously identified analogues (i.e., phttyearynol (compound 6), myricatomentogenin (compound 7), and juglanin D (compound 8)) were isolated from the stem bark of Platycarya strobilacea. The structures of these compounds were determined using NMR, HRESIMS, and electronic circular dichroism (ECD) data. The cytotoxicity of compounds 1–5 and their ability to inhibit nitric oxide (NO) production, as well as protect against the corticosterone-induced apoptosis of Pheochromocytoma (PC12) cells, were evaluated in vitro using the appropriate bioassays. Compounds 1 and 2 significantly inhibited the corticosterone-induced apoptosis of PC12 cells at a concentration of 20 μΜ. |
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| Keywords: | cyclic diarylheptanoid Platycarya strobilacea Juglandaceae corticosterone-induced apoptosis |
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