Phenolic glycosides from Lindera fruticosa root and their inhibitory activity on osteoclast differentiation |
| |
Authors: | Song Myoung-Chong Nigussie Fikru Yang Hye-Joung Kim Hong-Hee Kim Ji-Young Chung Dae-Kyun Baek Nam-In |
| |
Institution: | Graduate School of Biotechnology and Plant Metabolism Research Center, Kyung Hee University, Suwon, South Korea. |
| |
Abstract: | Two new compounds were found in the phenolic glycosides isolated from the roots of Lindera fruticosa: 5-O-beta-D-apiofuranosyl-(1'-->2')-O-beta-D-xylopyranosyl]gentisic acid-7,5'-ester (3), named linderofruticoside A; and 5-O-beta-D-apiofuranosyl-(1'-->3')-O-beta-D-xylopyranosyl]gentisic acid methyl ester (4), linderofruticoside B. Two previously known phenolic glycosides were also identified: beta-D-(3,4-disinapoyl)fructofuranosyl-alpha-D-(6-sinapoyl)glucopyranoside (1) and beta-D-(3-sinapoyl)fructofuranosyl-alpha-D-(6-sinapoyl)glucopyranoside (2). Compounds 1 and 2 inhibited osteoclast differentiation in a dose-dependent manner at concentrations higher than 1.04 microM and 0.132 microM, respectively. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|