Enantioselective Michael additions of aldehydes to nitroalkenes catalyzed with ionically tagged organocatalyst |
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| Authors: | Radovan ?ebesta Attila Latika |
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| Institution: | 1. Department of Organic Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, 84215, Bratislava, Slovakia
2. Synkola, 84215, Bratislava, Slovakia
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| Abstract: | Enantioselective organocatalytic Michael additions affords useful building blocks for many biologically and medicinally relevant compounds. Ionically-tagged diphenylprolinol silyl ether efficiently catalyzes several Michael additions of aldehydes to nitroalkenes in ionic liquids. The Michael additions work well in ionic liquids; yields up to 95% and enantioselectivities up to 95% ee were achieved. Furthermore, in some cases, the catalytic system was reusable. ![src=]() |
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