4,4-Difluoro-4-bora-3a,4a-diaza-s-indacene as a bright fluorescent label for DNA |
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| Authors: | Ehrenschwender Thomas Wagenknecht Hans-Achim |
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| Institution: | Institute for Organic Chemistry, University of Regensburg, Universit?tsstrasse 31, 93053 Regensburg, Germany. |
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| Abstract: | 4,4-Difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) as a fluorescent label can be incorporated into DNA by two conceptually different ways: the non-nucleosidic DNA base surrogate Bo exhibits high brightness but no preferential base-pairing properties, whereas the BODIPY-modified uridine BodU has reduced quantum yields but shows preferred Watson-Crick base pairing with adenine. |
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