首页 | 本学科首页   官方微博 | 高级检索  
     


Enhancing NMR Sensitivity of Natural‐Abundance Low‐γ Nuclei by Ultrafast Magic‐Angle‐Spinning Solid‐State NMR Spectroscopy
Authors:Dr. Rongchun Zhang  Yitian Chen  Prof. Dr. Nair Rodriguez‐Hornedo  Prof. Dr. Ayyalusamy Ramamoorthy
Affiliation:1. Biophysics and Department of Chemistry, The University of Michigan, Ann Arbor, Michigan, USA;2. Department of Pharmaceutical Science, The University of Michigan, Ann Arbor, Michigan, USA
Abstract:Although magic‐angle‐spinning (MAS) solid‐state NMR spectroscopy has been able to provide piercing atomic‐level insights into the structure and dynamics of various solids, the poor sensitivity has limited its widespread application, especially when the sample amount is limited. Herein, we demonstrate the feasibility of acquiring high S/N ratio natural‐abundance 13C NMR spectrum of a small amount of sample (≈2.0 mg) by using multiple‐contact cross polarization (MCP) under ultrafast MAS. As shown by our data from pharmaceutical compounds, the signal enhancement achieved depends on the number of CP contacts employed within a single scan, which depends on the T of protons. The use of MCP for fast 2D 1H/13C heteronuclear correlation experiments is also demonstrated. The significant signal enhancement can be greatly beneficial for the atomic‐resolution characterization of many types of crystalline solids including polymorphic drugs and nanomaterials.
Keywords:cross-polarization  NMR spectroscopy  signal enhancement  structure elucidation  ultrafast MAS
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号