A 'Sleeping Trojan Horse' which transports metal ions into cells, localises in nucleoli, and has potential for bimodal fluorescence/PET imaging |
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| Authors: | Thorp-Greenwood Flora L Fernández-Moreira Vanesa Millet Coralie O Williams Catrin F Cable Joanne Court Jonathan B Hayes Anthony J Lloyd David Coogan Michael P |
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| Affiliation: | Department of Chemistry, Cardiff University, Cardiff, Cymru/Wales, UK CF10 3AT. |
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| Abstract: | A rhenium polypyridine-based molecular vessel is membrane impermeant when empty, but, upon loading with metal ions, the cationic form is taken up by MCF-7 cells, localising in nucleoli. The luminescence of the vessel and its copper binding ability suggest potential as a bimodal fluorescence/PET imaging agent. |
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