Reactions of ethyl 3-(diethoxyphosphoryl)-3,3-difluoropyruvate with some nucleophilic reagents |
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| Authors: | P. V. Pasternak A. S. Golubev A. S. Peregudov N. D. Chkanikov |
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| Affiliation: | (1) A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 ul. Vavilova, 117813 Moscow, Russian Federation |
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| Abstract: | Reactions of ethyl 3-(diethoxyphosphoryl)-3,3-difluoro-2-oxopropionate with a number of nucleophilic reagents were studied. New procedures were developed for the synthesis of difluoromethylphosphonate-substituted nitrogen heterocycles. The ketoester under study is much less reactive in C-hydroxyalkylation of aromatic amines than methyl 3,3,3-trifluoropyruvate. Published inIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1258–1260, July, 2000. |
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| Keywords: | ethyl 3-(diethoxyphosphoryl)-3,3-difluoro-2-oxopropionate heterocyclization C-hydroxyalkylation N-hydroxyalkylation difluoromethylphosphonates imidazolines indoles indolines quinoxalines phenylhydrazones |
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