One-pot synthesis of simple alkaloids: 2,3-polymethylene-4(3H)-quinazolinones, luotonin A, tryptanthrin, and rutaecarpine |
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| Authors: | Jahng Katherine Chae Kim Seung Ill Kim Dong Hyeon Seo Chang Seob Son Jong-Keun Lee Seung Ho Lee Eung Seok Jahng Yurngdong |
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| Institution: | College of Pharmacy, Yeungnam University, Gyeongsan, Korea. ydjahng@ynu.ac.kr |
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| Abstract: | One-pot synthesis of various 2,3-polymethylene-4(3H)-quinazolinones from anthranilic acid, corresponding lactam and SOCl(2) is described, which can be applicable to the synthesis of simple 4(3H)-quinazolinone-derived alkaloids, such as luotonin A, tryptanthrin, and rutaecarpine. |
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