Remarkable photocytotoxicity of curcumin in HeLa cells in visible light and arresting its degradation on oxovanadium(IV) complex formation |
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| Authors: | Banerjee Samya Prasad Puja Hussain Akhtar Khan Imran Kondaiah Paturu Chakravarty Akhil R |
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| Institution: | Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560012, India. |
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| Abstract: | Curcumin (Hcur) as a cellular imaging and PDT agent shows remarkable photocytotoxicity in HeLa cells in visible light of 400-700 nm giving IC(50) = 8.2 ± 0.2 μM and its degradation is arrested on formation of photocytotoxic dipyridophenazine (dppz) complex VO(cur)(dppz)Cl] (IC(50) = 3.3 ± 0.4 μM), while both are less toxic in the dark. |
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