An expert system for the selection of criteria for selectivity optimization in high-pressure liquid chromatography |
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Authors: | Anne Peeters Lutgarde Buydens Desire L. Massart P. J. Schoenmakers |
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Affiliation: | (1) Farmaceutisch Instituut, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium;(2) Philips Research, P.O. Box 80000, 5600 JA Eindhoven, The Netherlands |
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Abstract: | Summary Systematic procedures for the optimization of chromatographic selectivity require objective criteria to characterize the quality of separation in a chromatogram. Numerous criteria have been suggested. Different criteria yield different results and the choice will depend on a large number of factors. It is genuinely difficult to select the most suitable criterion in a particular situation. For these reasons, an expert system has been developed to assist chromatographers in the selection of optimization criteria. A structured representation of the required knowledge and its implementation in an expert-system shell are presented in this paper. |
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Keywords: | Column liquid chromatography Expert systems Selectivity optimization Optimization criteria |
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