An expeditious route toward pyrazine-containing nucleoside analogues |
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Authors: | Modha Sachin G Trivedi Jalpa C Mehta Vaibhav P Ermolat'ev Denis S Van der Eycken Erik V |
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Institution: | Department of Chemistry, Katholieke Universiteit Leuven, Belgium. |
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Abstract: | An improved and convenient methodology for the synthesis of asymmetrically substituted pyrazines starting from 3,5-dichloropyrazin-2(1H)-ones has been elaborated. Several nucleoside analogues have been synthesized containing the pyrazine core as the organic base coupled with the sugar via a triazole linkage. The beneficial effect of microwave irradiation throughout the sequence has been demonstrated. |
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