4-Deacetylbaccatin III: a proposed biosynthetic precursor of paclitaxel from the bark of Taxus wallichiana |
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| Authors: | Nisar Muhammad Qayum Mughal Adhikari Achyut Khan Inamullah Kaleem Waqar Ahamad Ali Zulfiqar Choudhary M Iqbal |
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| Affiliation: | Institute of Chemical Sciences, University of Peshawar, Peshawar-25120, NWFP, Pakistan. |
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| Abstract: | 4-Deacetylbaccatin III was isolated and characterized from the bark of Taxus wallichiana Zucc. It was previously identified as an intermediate during the synthesis of paclitaxel and was proposed as a precursor for the biosynthesis of paclitaxel. Existence of 4-deacetylbaccatin III in T. wallichiana is strong evidence for the previously proposed biosynthetic pathway of paclitaxel via 4-deacetylbaccatin III. |
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