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| 无溶剂条件下5,6-二取代-2,3-吡啶二酮的合成 | |
| 引用本文： | 谢文林,肖桂武,古练权. 无溶剂条件下5,6-二取代-2,3-吡啶二酮的合成[J]. 有机化学, 2008, 28(6): 1123-1125 |
| 作者姓名： | 谢文林 肖桂武 古练权 |
| 作者单位： | 1. 湖南科技大学化学化工学院,分子构效关系湖南省高校重点实验室,湘潭,411201 2. 中山大学化学与化学工程学院,广州,510275 |
| 基金项目： | 湖南省社会科学基金，湖南科技大学校科研和教改项目 |
| 摘 要： | 在无溶剂条件下, 由3-羟基-2(1H)-吡啶酮与取代苯胺在NaIO3作用下合成了一系列5,6-二取代-2,3-吡啶二酮, 产物结构由元素分析, 1H NMR, MS, IR得到确认. 该方法具有反应条件温和、操作简单和产率高等优点. |
| 关 键 词： | 合成 2,3-吡啶二酮 无溶剂 研磨 |
| 收稿时间： | 2008-02-20 |
| 修稿时间： | 2008-02-20 |
Solvent-Free Synthesis of 5,6-Disubstituted-pyridine-2,3-diones |
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| XIE,Wen-Lin,XIAO,Gui-Wu,GU,Lian-Quan. Solvent-Free Synthesis of 5,6-Disubstituted-pyridine-2,3-diones[J]. Chinese Journal of Organic Chemistry, 2008, 28(6): 1123-1125 | |
| Authors: | XIE Wen-Lin XIAO Gui-Wu GU Lian-Quan |
| Affiliation: | (a Key Laboratory of QSAR/QSPR of Hunan Provincial University, School of Chemistry and Chemi-cal Engineering, Hunan University of Science and Technology, Xiangtan 411201) (b School of Chemistry and Chemical Engineering, Zhongshan University, Guangzhou 510275) |
| Abstract: | 5,6-Disubstituted-pyridine-2,3-diones were synthesized via the reaction of 3-hydroxy- 1H-pyridin-2-ones with anilines in the presence of NaIO3 under solvent-free conditions by grinding. The structures of the products were identified by 1H NMR, MS, IR techniques and elemental analysis. The method offered several advantages including mild reaction conditions, simple experimental procedure and high yields. |
| Keywords: | synthesis pyridine-2,3-dione solvent-free grinding |
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