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Highly enantioselective alkynylation of aldehydes catalyzed by a readily available chiral amino alcohol-based ligand
Authors:Jiang Biao  Chen Zili  Xiong Wennan
Institution:State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China. jiangb@pub.sioc.ac.cn
Abstract:A new inexpensive chiral amino alcohol-based ligand, (1S,2S)-2-N,N-dimethylamino-1-(p-nitrophenyl)-3- (t-butyldimethylsilyloxy)propane-1-ol, was developed for the asymmetric alkynylation of aliphatic and aromatic aldehydes, to prepare the corresponding propargylic alcohols in high yields with up to 99% ee.
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