Highly enantioselective alkynylation of aldehydes catalyzed by a readily available chiral amino alcohol-based ligand |
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Authors: | Jiang Biao Chen Zili Xiong Wennan |
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Institution: | State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China. jiangb@pub.sioc.ac.cn |
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Abstract: | A new inexpensive chiral amino alcohol-based ligand, (1S,2S)-2-N,N-dimethylamino-1-(p-nitrophenyl)-3- (t-butyldimethylsilyloxy)propane-1-ol, was developed for the asymmetric alkynylation of aliphatic and aromatic aldehydes, to prepare the corresponding propargylic alcohols in high yields with up to 99% ee. |
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