高效液相色谱法测定硝苯地平片含量及其含量均匀度

采用高效液相色谱法测定了硝苯地平片含量及其含量均匀度。色谱柱为C18柱，流动相为V（甲醇）：V（三乙胺缓冲液，pH5．20）=68:32，紫外检测器，检测波长为237um。在此色谱条件下可得到较宽的线性范围和较高的回收率，其分解产物亦可得到良好的分离。

Determination of Nifedipine Content and its Uniformity in Tablets by High Performance Liquid Chromatography

An HPLC method with diazepam as internal standard was developed to determine nifedipine content and its uniformity in tablets. The analytical column was a C18 column, the mobile phase consisted of V (methanol): V(triethylamine,pH 5. 20)=68: 32. The detection was carried out with UV detector (A=237 nm). Under this condition, the linear range was wide (8-80 mg/L) and the recovery was high (99. 86% ).The proposed method is simple and accurate and the decomposed product can be separated as well. Therefore,the quality of nifedipine tablets can be effectively controlled.