| 固载化酶催化合成多肽的研究进展 |
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| 引用本文： | 刘平,田桂玲,叶蕴华. 固载化酶催化合成多肽的研究进展[J]. 高等学校化学学报, 2001, 22(8): 1342-1348 |
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| 作者姓名： | 刘平 田桂玲 叶蕴华 |
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| 作者单位： | 生物有机与分子工程教育部重点实验室, 北京大学化学与分子工程学院, 北京 100871 |
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| 基金项目： | 国家教育部博士学科点专项基金 (批准号 :970 0 0 12 0 )，香港理工大学资助 |
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| 摘 要： | 评述了溶剂、载体性质与固载化方法、pH值、底物浓度以及反应温度等因素对固载化酶催化合成肽反应的影响,并概括了固载化酶催化合成生物活性肽、寡肽等方面的研究与应用.
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| 关 键 词： | 固载化酶 酶催化反应 肽 亲水性 疏水性 |
| 文章编号： | 0251-0790(2001)08-1342-07 |
| 收稿时间： | 2000-08-29 |
Progress in the Study on Peptide Synthesis Catalyzed by Immobilized Enzyme |
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| LIU Ping,TIAN Gui-Ling,YE Yun-Hua. Progress in the Study on Peptide Synthesis Catalyzed by Immobilized Enzyme[J]. Chemical Research In Chinese Universities, 2001, 22(8): 1342-1348 |
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| Authors: | LIU Ping TIAN Gui-Ling YE Yun-Hua |
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| Affiliation: | Key Laboratory of Bioorganic Chemistry and Molecular Engineering for Educational Ministry, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China |
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| Abstract: | The review deals with the factors which have influence on peptide synthesis catalyzed by immobilized enzyme and its application for peptide synthesis. Particular attention is paid to important effect factors, such as solvent, support, pH value, etc . and the reasons for these effects are discussed. Immobilized enzymes applied to peptide synthesis, i.e., sweetener aspartame, enkephalin and other bioactive peptides and so on, were briefly summarized. |
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| Keywords: | Immobilized enzyme Enzymatic reaction Peptide Hydrophilicity Hydrophobicity |
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