Solid-phase synthesis of bleomycin group antibiotics. Elaboration of deglycobleomycin A(5) |
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| Authors: | Leitheiser C J Rishel M J Wu X Hecht S M |
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| Affiliation: | Departments of Chemistry and Biology, University of Virginia, Charlottesville, Virginia 22901, USA. |
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| Abstract: | The solid-phase syntheses of two deglycobleomycin A(5) analogues were achieved using a commercially available polystyrene resin containing triphenylmethyl-linked spermidine. The final products were deblocked and released from the resin, analyzed, and purified by C(18) reversed phase HPLC and characterized by high-field (1)H NMR spectroscopy and mass spectrometry. The purified products relaxed supercoiled plasmid DNA in a concentration-dependent fashion and to the same extent as authentic material derived from natural BLM A(5). |
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