(3R,4aR,5S,6R)-6-Hydroxy-5-methylramulosin: a new ramulosin derivative from a marine-derived sterile mycelium |
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Authors: | El-Beih Ahmed Atef Kato Hikaru Ohta Tomihisa Tsukamoto Sachiko |
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Institution: | Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa, Japan. |
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Abstract: | (3R,4aR,5S,6R)-6-Hydroxy-5-methylramulosin (1) was isolated from a culture of a sterile mycelium, which was derived from the green alga, Codium fragile, along with (-)-5-methylmellein (2), (-)-5-hydroxymethylmellein (3), and (-)-(3R,4R)-cis-4-hydroxy-5-methylmellein (4). The absolute configuration of 1 was determined by the NMR data along with the lactone sector rule by circular dichroism (CD). Compound 1 exhibited moderate cytotoxic activity against HeLa cells. |
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