以赖氨酸为配基的内毒素吸附剂的研究

内毒素血症可出现于多种疾病中，如大面积烧伤、重症肝炎、肝硬化等疾病，使机体免疫功能严重受损，引起多器官功能衰竭等一系列严重的病理变化，最终导致不可逆休克和死亡，在美国每年都有超过10万人死于此病，临床上尚无有效的治疗方法，因此，及时、有效地清除或破坏患者体内的内毒素，

Hemperfusion Adsorbents With Lysine as Ligand for Removing of Endotoxin

Endotoxin is lipopolysaccharide(LPS) derived from the cell membrane of gram-negative bacteria. The concentration of endotoxin in endotoxemia patients′ blood increases quickly and leads to severe sepsis, leading to severe hypertension, cardiovascular continues to have a high failure and death, which is a major cause of death in patients and continues to have a high mortality despite appropriate surgery, potent antibiotic and intensive supportive therapy was conducted. Removal of endotoxin duly and effectually from patients′ blood is very important in clinic. Hemoperfusion can clear toxins from patient′s blood by adsorbent, not only small molecular toxins but also large ones in time. In this paper, the hemoperfusion adsorbent for removing endotoxin was prepared. The physical and chemical parameter of the adsorbent is investigated and the surface structure of adsorbent was investigated through ESEM. The influence of weights of adsorbents and adsorbing time on adsorption ability was also studied. The results showed that the adsorbent with lysine as the ligand had good affinity to endotoxin and the best adsorption capacity of it was 253.1 EU/g when the initial concentration is 10 EU/mL. The blood compatibility of the adsorbent was also studied and the results indicated that the adsorbent has clinic application foreground.