Application of high-performance liquid chromatography hyphenated techniques for identification of degradation products of cefpodoxime proxetil |
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Authors: | Fukutsu Naoto Kawasaki Takao Saito Koichi Nakazawa Hiroyuki |
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Institution: | Analytical and Quality Evaluation Research Laboratories, Sankyo Co Ltd, 1-12-1 Shinomiya, Hiratsuka-shi, Kanagawa, Japan. fukutu@sankyo.co.jp |
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Abstract: | Application of the HPLC hyphenated techniques of LC-MS, LC-NMR and solvent-elimination LC-IR was demonstrated by the identification of the degradation products of a third generation cephalosporin antibiotic, cefpodoxime proxetil, in solid state, drug formulation and solution. Molecular weight and fragment information were obtained by LC-MS, and detailed structural information was confirmed by LC-NMR. Information on the carboxyl functional group obtained by solvent-elimination LC-IR was useful for confirmation of the ester hydrolysis. The degradation products were successfully identified without complicated isolation or purification processes. |
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